Journal of AdvancedMedical and Dental Sciences Research

Background: To study the drug resistance pattern in tuberculosis. Materials & Methods: A collection of Mycobacterial strains was gathered from 100 patients who had been diagnosed with smear-positive tuberculosis. These strains were subjected to testing for susceptibility to drugs such as ethambutol, isoniazid, and streptomycin. Additionally, multiple logistic regression analysis was conducted to pinpoint the risk factors associated with MDR-TB. The strength of these associations was quantified using odds ratios (OR) with a 95% confidence interval (95% CI), and statistical significance was considered when the two-tailed p-value was less than 0.05. Results: A total of 100 cases were evaluated. Among them, 86 subjects were older and remaining were the new cases. The smear was taken and examined. The study found a significant association between an initial smear grading of 2+ and 3+ and drug-resistant tuberculosis (p=0.02). However, this same association did not hold importance in the context of multidrug-resistant tuberculosis (MDR-TB) (p=0.7). Conclusion: The primary factors contributing to the development of multidrug-resistant tuberculosis (MDR-TB) were individuals under the age of 48, a history of previous TB treatment, and having a positive smear at the end of the second month of treatment.