Journal of AdvancedMedical and Dental Sciences Research

Background: Acute kidney injury is a sudden and rapid deterioration in kidney function. It is a serious condition that occurs over a short period of time and can have a significant impact on overall health. The present study evaluated clinical profile of patients with acute kidney injury (AKI) and liver cirrhosis. Materials & Methods: 86 patients of cirrhosis of the liver and acute kidney injury of both genders were enrolled. Staging of AKI, and risk factors for cirrhosis was recorded. Patients were divided into three groups. Group I comprised of pre-renal azotemia, group II hepatorenal syndrome, and group III acute tubular necrosis. Child’s and model for end stage liver disease (MELDs) scores, creatinine at admission, eGFR at admission and Child- Pugh score was recorded. Hospital stay were also recorded in all groups. Results: Group I had 16 males and 14 females, group II had 20 males and 15 females and group III had 11 males and 10 females. In group I, II and III, AKI stage 1 was seen in 7, 6 and 4, stage 2 in 8, 9 and 6 and stage 3 in 15, 20 and 11 respectively. Etiology for cirrhosis was alcohol in 12, 9 and 6, Hepatitis B in 10, 11 and 8, Hepatitis C in 9, 8 and 4, cryptogenic in 4, 7 and 3 respectively. The difference was significant (P< 0.05). Creatinine at admission was 1.7 mg/dL, 3.4 mg/dL and 2.5 mg/dL. eGFR at admission was 39.4 mL/min/1.73 m2, 27.5 mL/min/1.73 m2 and 36.2 mL/min/1.73 m2. MELD score was 28.3, 21.5 and 32.8, Child- Pugh score was 10.5, 10.8 and 11.2. Hospital stay was 11.2 days, 10.1 days and 11.3 days in group I, II and III respectively. The difference was non- significant (P>0.05). Conclusion: Acute kidney injuries in liver cirrhosis are associated with high in-hospital mortality. MELD score and Child- Pugh score can be considered as indicator of AKI.