Journal of AdvancedMedical and Dental Sciences Research

Aim: This study aims to investigate the levels of serum uric acid in individuals with essential hypertension, with a particular focus on the impact of age and body mass index. Methods: This study comprised a sample of 100 individuals diagnosed with hypertension and 100 age and sex-matched healthy participants with normal blood pressure. The uricase method was employed to measure the serum uric acid level, while the Jaffe method was utilized to measure the serum creatinine. Additionally, the enzymatic method was employed to measure the triglyceride, total cholesterol, and HDL cholesterol. The Friedewald equation was utilized to compute the LDL-cholesterol. The glucose oxidase method was employed to measure glucose levels in venous blood samples that were collected in EDTA tubes. The Cockroft-Gault formula was utilized to compute the estimated glomerular filtration rate (eGFR). The condition of hyperuricemia is characterized by serum uric acid (SUA) levels that exceed 7.0 mg/dL in males and 6.0 mg/dL in females. Results: The prevalence of hyperuricemia was found to be significantly greater in the hypertensive cohort as compared to the normotensive control cohort (31% vs. 6%, p<0.001). The results indicate that the hypertensive individuals had a significantly elevated serum uric acid level compared to the control group (mean±SD: 6.22±0.80 vs. 5.50±0.46 mg/dL, p<0.001). The results indicate that individuals with stage II hypertension exhibited elevated levels of serum uric acid in comparison to those with stage I hypertension (mean±SD: 6.55±0.72 vs. 5.81±0.67 mg/dL, p<0.001). The results indicate that within the hypertensive group, there were significant positive correlations observed between uric acid levels and both systolic and diastolic blood pressure. However, in the control group, a positive correlation between uric acid levels and systolic blood pressure was observed exclusively. Conclusion: The study found that individuals diagnosed with essential hypertension exhibited elevated levels of serum uric acid in comparison to normotensive controls. Furthermore, patients diagnosed with stage II hypertension demonstrated higher levels of uric acid in comparison to those diagnosed with stage I hypertension. The study found that there was a significant positive correlation between the serum uric acid level and both systolic and diastolic blood pressure in individuals with hypertension.