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Volume 4 Issue 4 (July - August, 2016)

Original Articles

EVALUATION OF SERUM ANTIOXIDANT ENZYMES IN ORAL SUBMUCOUS FIBROSIS AND ORAL SQUAMOUS CELL CARCINOMA- A CLINICAL AND BIOCHEMICAL STUDY
Sanjay B. Nyamati, Annapoorna H.B, Juhi Tripathi, Neha Sinha, Shraddha Roy, Ruchika Agrawal

Background Present study was aimed to estimate the levels of glutathione peroxidase, malondialdehyde (MDA), superoxide distmutase (SOD) in oral submucous fibrosis (OSMF), and oral squamous cell carcinoma patients. Materials and Methods: Blood samples were collected from 30 patients who were divided into three groups: Group I as control with 10 normal individuals, group II with histopathologically confirmed different cases of OSMF, and group III with histopathologically confirmed cases of oral squamous cell carcinoma (OSCC). Results obtained were statistically analyzed.  Results: Superoxide dismutase (SOD) and Malondialdehyde (MDA) was demonstrated significantly more in case of control group in comparison to OSMF and OSCC group whereas Glutathione peroxidase (GPx) was found significantly higher in OSF and OSCC group. Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) was found to be significantly more in OSF group in comparison to OSCC patients and levels of MDA was observed higher in OSCC patients. The P-value was calculated and the results were highly significant. Conclusion: SOD, GPx, MDA can be used as valid biomarkers for patients who are at risk of developing cancer.
Key words: MDA, oral squamous cell carcinoma, oral submucous fibrosis, SOD.

Corresponding Author:  Dr. Sanjay B. Nyamati, Principal, Professor & Head, Department of Oral Medicine and Radiology, Triveni Institute of Dental Sciences, Hospital and Research Centre, Bilaspur, Chhatisgarh

This article may be cited as: Nyamati SB, HB Annapoorna., Tripathi J, Sinha N, Roy S, Agrawal R Evaluation of serum antioxidant enzymes in oral submucous fibrosis and oral squamous cell carcinoma: A clinical and biochemical study. J Adv Med Dent Scie Res 2016;4(4):83-87.

 
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