Journal of AdvancedMedical and Dental Sciences Research

Aim: The purpose of this research was to determine whether or not a dressing containing octenidine dihydrochloride or a dressing containing saline is more successful in treating diabetic foot ulcers. Material and methods: The Department of General Surgery was the location of this prospective comparative study that was carried out. This research comprised a total of 200 patients, with persistent DFU symptoms; 100 patients were assigned to each of the two treatment arms (saline dressing group and octenidine dihydrochloride dressing group), for a total of 200 patients. In one group, regular wound dressings were done using octenidine dihydrochloride topical ointment, while in the other group, regular wound dressings were done with saline. Over the course of the trial, the wounds were evaluated on a regular basis to see how well they were healing. Results: The octenidine dihydrochloride group had a mean age of 56.96 ±4.59 years, whereas the saline dressing group had a mean age of 57.99±5.63 years. Approximately 39% of people in the octenidine dihydrochloride group and 35% of people in the saline group had a habit of drinking alcohol. About 51% of people in the saline group smoked cigarettes, whereas only 49% of people in the octenidine dihydrochloride group did so. In addition to the blood tests that were performed, the concentration of haemoglobin (Hb) was taken into account for the statistical analysis. In the saline group, the mean surface area of the wound at baseline was 10.9 square centimeters; in the octenidine dihydrochloride group, the mean surface area of the wound at baseline was 12.4 square centimeters; in the 2nd week, it was 10.2 square centimeters; in the 4th week, it was 9.6 square centimeters; and in the 6th week, it was 8.2 square centimeters. Conclusions: We came to the conclusion that the dressing containing octenidine dihydrochloride is more efficient than the dressing containing saline when it comes to attaining quick wound healing, avoiding infections, and reducing morbidity in patients who have chronic DFU. In addition, octenidine dihydrochloride dressing has wide range anti-microbial action, which eliminates the biofilm that usually develops in diabetic patients. Because of this, octenidine dihydrochloride dressing is recommended for patients with chronic DFU rather than saline dressing.