Journal of AdvancedMedical and Dental Sciences Research

Background: Migraine is a common and disabling health problem and the primary goals of preventive treatment are to reduce attack frequency, severity, and duration. The present study compared propranolol and flunarizine in prophylaxis of migraine. Materials & Methods: 80 patients of migraine of both genders were divided into 2 groups of 40 each. In group I, patients received propranolol 20 to 160mg/day and group II patients received flunarizine 5 to 10mg/day for three months. Results: Group I had 18 males and 22 females and group II had 15 males and 25 females. The mean duration of migraine was 21.5 minutes and 21.8 minutes. The mean frequency/month of migraine was 5.03 and 5.17, MIDAS was 10.9, 10.2 and VAS was 6.6 and 5.4 in group I and group II respectively. The difference was non- significant (P> 0.05). Adverse events were hair loss in 1 in group II, tremors in 1 in group I and 2 in group II, dizziness in 1 in group I, weight gain in 1 in group I and 2 in group II and insomnia in 1 in group II. The difference was non- significant (P> 0.05). Conclusion: Bothpropranolol and flunarizinedrugs found to be equally effective in management of cases of migraine.