Journal of AdvancedMedical and Dental Sciences Research

Background: Postpartum haemorrhage (PPH) is one of the leading causes of maternal mortality with uterine atony being the cause in about 50% cases. The present study was conducted to evaluate effect of phenylephrine with oxytocin on the prevention of oxytocin induced hypotension in caesarean section under spinal anaesthesia. Materials & Methods: 60 females in age ranged 18- 50 years with elective and emergency lowersegment caesarean section (LSCS) were divided into 3 groups of 20 each. Group I patients received oxytocin 3U and phenylephrine 50 µg diluted to 10cc with normal saline as an infusion over 5 minutes, group II patients received oxytocin 3U and phenylephrine 75 µg diluted to 10cc infusion over 5 minutes and group III patients received oxytocin 3U and normal saline diluted to 10cc infusion over 5 minutes. Results: The mean age in group I was 26.2 years, in group II was 27.4 years and in group III was 27.1 years. The mean height was 160.2 cm in group I, 159.5 cm in group II and 161.1 cm in group III. The mean weight was 64.4 kgs in group I, 63.2 kgs in group II and 65.5 kgs in group III. The difference was non- significant (P> 0.05). The duration of surgery was 51.3 minutes in group I, 54.2 minutes in group II and 53.8 minutes in group III. Extraction time of baby from induction was 11.8 minutes, 10.4 minutes and 11.8 minutes and extraction time of baby from skin incision was 6.2 minutes, 7.5 minutes and 7.2 minutes in group I, II and III respectively. Dose of rescue vasopressor given (µg) was 44.3, 5.4 and 90.4. Incidence of hypotension was seen in 12 in group I, 3 in group II and 15 in group III. The difference was non- significant (P> 0.05). Episodes of hypotension was 0 seen in 8 in group I, 17 in group II and 5 in group III. 1 seen in 10 in group I, 3 in group II and 13 in group III. 2 seen in 2, 0 and 2 respectively. MAPbefore oxytocin infusion was 80.2, 81.4 and 76.8 and MAP after oxytocin infusion was 64.2, 75.9 and 65.4 in group I, II and III respectively. The difference was non- significant (P> 0.05) Conclusion: Co-administration of phenylephrine 75 µg with oxytocin 3U reduces the incidence of oxytocin-induced hypotension compared to phenylephrine 50 µg with oxytocin 3U during caesarean section under spinal anaesthesia.