Journal of AdvancedMedical and Dental Sciences Research

Background: Post-operative sore throat (POST) and hoarseness of voice are common complaints from patients receiving tracheal intubation. The present study was conducted to assess role of inhaled budesonide suspension on occurrence of POST in surgical patients following endotracheal intubation. Materials & Methods: 110 patients scheduled for short electivelaparoscopic surgeries under generalanaesthesia with endotracheal intubationwere divided into 2 groups of 55 each. Group I received 200 µg budesonide inhalation suspension, using a metered dose inhaler, 10 min before intubation, and repeated 6 hours after extubation. In group II, no such intervention was performed. The incidence and severity of POST was recorded in all patients. The incidence of post-operative hoarseness and cough was also recorded. Results: There were 30 males and 25 females in group I and 28 males and 27 females in group II. ASA statusI was seen in 30 males and 25 females in group I and II in 30 males and 25 females. Mallampatti score1 was seen in 32 in group I and 36 in group II. Score 2 was seen in 25 in group I and 19 in group II. Number of attempts atintubation was 1 in 50 and 42 and 2 seen among 5 and 13 in group I and II respectively. Rescue therapy for POST was seen among 6 in group I and 20 in group II. The difference was significant (P< 0.05).POST at 2 hours, 6 hours, 12 hours and 24 hours was seen in 27% and 82%, 14% and 80%, 5% and 78% and 1% and 71% in group I and II respectively. The difference was significant (P< 0.05). Hoarseness of voice at 2 hours was 30% and 52%, at 6 hours was 22% and 43%, at 12 hours was 0 and 30% and at 24 hours was 0 and 5% in group I and II respectively. Post‑operative cough in group I and group II at 2 hours was 38% and 74%, at 6 hours was 16% and 52%, at 12 hours was 12% and 48% and at 24 hours was 2% and 5% in group I and II respectively. The difference was significant (P< 0.05). Conclusion: Inhaled budesonide suspension significantly reduced the incidence and severity of POST in surgical patients following endotracheal intubation.