Journal of AdvancedMedical and Dental Sciences Research

Background: The use of neuromuscular blocking agents (NMBA) to facilitate tracheal intubation is a widely accepted procedure. Direct laryngoscopy stimulates the oropharynx and activates oropharyngeal reflexes. The present study compared Vecuronium and Rocuronium bromide for laryngoscopy. Materials & Methods: 50 ASA grade I and grade II patients from different surgical specialties of both genders. Patients were divided into 2 groups of 25 each. Group I patients received Inj. Rocuronium and group II patients received Inj. Vecuronium. Parameters such as onset of action, intubating conditions, heart rate and train of four monitoring was recorded. Time in seconds from injection of study drug till TOF score 0 (onset time) and duration of action were measured by intermittently noting response to TOF. Results: Group I patients received Inj. Rocuronium and group II patients received Inj. Vecuronium. Group I had 13 males and 12 females and group II had 14 males and 11 females. The mean duration of action was 43.6 minutes in group I and 47.5 minutes in group II and train of four monitoring was 63.4 seconds in group I and 140.2 seconds in group II. Intra-operative laryngoscopy status was easy in all 25 patients in both groups. The difference was significant (P< 0.05). The mean heart rate (beats/min) at baseline in group I was 81.4 and in group II was 83.2, after intubation in group I was 90.4 and I group II was 93.6 and after 10 minutes in group I was 81.6 and in group II was 84.1. The difference was significant (P< 0.05). Conclusion: There was no difference in intubating conditions and haemodynamic response between both agents. Both Rocuronium and Vecuronium were found to be equally effective.