Journal of AdvancedMedical and Dental Sciences Research

Background: Benign prostatic hyperplasia (BPH) is the most common neoplastic condition afflicting men and constitutes a major factor impacting the health of the male. The present study compared tamsulosin and tadalafil in relieving benign prostatic hyperplasia related symptoms in males. Materials & Methods: 90 males of >45 years of age with LUTS were divided into 2 groupss. In group I, Tadalafil 10 mg once daily with an intervening 4-week period of placebo (P4) wash out followed by Tamsulosin 0.4 mg once daily were administered for a period of 6 weeks and in group II, reverse of it was administered. Parameters such as IPSS scores, uroflowmetry parameters and International Index of Erectile Function-5 scores were recorded. Results: Age group 45- 55 years had 8, 55-65 years had 20 and >65 years had 52 patients. The difference was significant (P< 0.05). Comorbidities such as diabetes mellitus was present in 2 in group I and 4 in group II, bronchial asthma 4 in group I and 2 in group II, hypertension was present in 6 in group I and 7 in group II and both hypertension and diabetes mellitus was present in 3 in group I and 5 in group II. The mean IPSS total score at baseline in group I was 17.4 and 16.7 in group II, at 2 weeks was 16.2 in group I and 16.3 in group II and at 8 weeks was 9.0 in group I and 9.3 in group II. IPSS voiding score at baseline in group I was 11.2 and 10.4 in group II, at 2 weeks was 10.0 in group I and 9.9 in group II and at 8 weeks was 5.1 in group I and 6.2 in group II. IPSS storage score at baseline in group I was 5.0 and 4.9 in group II, at 2 weeks was 4.5 in group I and 4.3 in group II and at 8 weeks was 2.9 in group I and 2.8 in group II. IPSS QOL score at baseline in group I was 2.8 and 4.4 in group II, at 2 weeks was 2.6 in group I and 3.9 in group II and at 8 weeks was 2.4 in group I and 2.1 in group II. The difference was non- significant (P> 0.05). Conclusion: Benign prostrate hyperplasia is frequent comlaint in men above 45 years of age. Both Tadalafil and Tamsulosin improved LUTS and benign prostrate hyperplasia symptoms.