Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was undertaken for assessing the microbiological profile and antibiotic sensitivity pattern of spontaneous bacterial peritonitis in patients of cirrhosis with ascites. Materials & methods: A total of 100 patients were enrolled. Complete demographic and clinical details of all the patients was obtained. The physical examination including BP, Pulse, Icterus, detailed general examination and systemic examination including abdominal Palpation of liver, spleen. SBP was identified and its microbiological profile was assessed. Diagnostic paracentesis was done within 24 hrs of admission under aseptic conditions or whenever peritonitis was suspected. Ascitic fluid was sent for Culture analysis and for evaluation of antibiotic susceptibility pattern. Results: Out of 100 patients, overall, SBP was present in 10 percent of the patients. All of them were AF culture positive. Out of 10 patients with culture positive SBP, E.coli was found in 60 percent of the patients while Klebsiella spp and Streptococcus spp were found in 30 percent and 10 percent of the patients.Among the Klebsiella spp., multidrug resistance was seen in 2 cases out of 3 cases. Norfloxacin, Ceftriaxone and Amoxicillin/clauvanic acid resistant sensitivity was seen in 1, 2 and 1 case respectively. Among the E.Coli., multidrug resistance was seen in 2 cases out of 6 cases. Norfloxacin, Ceftriaxone and Amoxicillin/clauvanic acid resistant sensitivity was seen in 3, 2 and 2 case respectively. Among the streptococcus spp, multidrug resistance was seen in 1 case. Norfloxacin, Ceftriaxone and Amoxicillin/clauvanic acid resistant sensitivity was seen in 1, 0 and 1 case respectively. Conclusion: Antibiotic prophylaxis and treatment of SBP should carefully take into account potential differences in the microorganisms causing SBP and antibiotic resistance patterns.