Journal of AdvancedMedical and Dental Sciences Research

Aim: To evaluate role of glycosylated haemoglobin as a biomarker in dyslipidemia and atherogenicity in type 2 diabetes mellitus. Methods: This research was carried out at the Department of Medicine. This research included 130 diagnosed instances of type 2 diabetes in people aged 19 to 68. The patients were separated into two groups based on their glycated haemoglobin levels. After at least 6 hours of fasting, venous blood samples from all subjects were collected and analysed for fasting plasma glucose (FPG), 2 hours post prandial glucose levels (2hPG), serum total cholesterol (TC), triglycerides (TG), HDL-C, Very low density lipoprotein cholesterol (VLDL-C), and LDL-C using standard methods. The atherogenic index of plasma (AIP) was determined using the base 10 logarithm of the TG/HDL-C ratio. Results: There were 60 men and 70 females among the 130 cases investigated. The majority of patients were between the ages of 55-65. FBG, TC, TG,VLDL-C, LDL-C, HbA1c, AIP, ratios of TC/HDL-C and LDL-C/HDL-C are higher in patients with HbA1c more than 7%, whereas HDL-C levels are lower in individuals with HbA1c less than 7%, and these differences are highly significant. Dylipidemia was the most prevalent characteristic in the lipid profile of patients with HbA1c levels more than 7%. HbA1c had a direct and substantial connection with FBG and 2Hpg. It also indicates a direct and very significant relationship between HbA1c and TC, TG, LDL-C, TC/HDL-C, LDL-C/HDL-C, and AIP, as well as an inverse relationship between HbA1c and HDL. Patients with HbA1c >7% were more prone to cardiovascular risk because their AIP levels were in the high risk category, i.e. AIP > 0.22, and the connection was highly significant, demonstrating that glycemic management greatly adds to the future risk of cardiovascular issues. The lipid characteristics of individuals with HbA1c <7% were normal, while the AIP levels remained in the danger category. Conclusion: The current research concludes that individuals with poor glycemic control have an atherogenic lipid profile, and Glycated haemoglobin predicts dyslipidemia and atherogenicity.