Journal of AdvancedMedical and Dental Sciences Research

Background: Bacterial vaginosis (BV) represents a synergistic polymicrobial syndrome, in which the normal protective lactobacilli are replaced with large quantities of commensal anaerobes. The present study was conducted to compare efficacy and tolerability of oral metronidazole and tinidazole in patients with bacterialvaginosis. Materials & Methods: 86 female patients of bacterial vaginosis were divided into 2 groups of 43 each. Group I patients received tablet metronidazole 500 mg twice daily for 5 days and in group II, tablet tinidazole 500 mg once daily + one placebo for 5 days and instructed to come for follow up at the 1st week and 4th week. They were categorized as cured, partially cured, and not cured based on Amsel’s criteria. Results: At follow-up at 1st week cure cases were 38 in group I and 40 in group II, partially cured were 5 and 3 and at follow‑up at 4th weeks had cure cases in 32 and 36, partially cured in 4 and 7 and not cured in 4 cases in group I. The difference was significant (P< 0.05). Conclusion: Tinidazole offers a better efficacy than metronidazole in patients withBacterial vaginosis