Journal of AdvancedMedical and Dental Sciences Research

Background: Parathyroid hormone (PTH) is an 84-amino-acid peptide, synthesized and released by parathyroid chief cells in response to hypocalcemia. Primary hyperparathyroidism (PHPT) results from inappropriate overproduction of parathyroid hormone from one or many parathyroid glands and presents with hypercalcemia. Hence; we planned the present study to evaluate the level of PTH intraoperatively and postoperatively. Materials & methods: A total of 30 patients were included in the present study that fulfilled the inclusion and exclusion criteria and reported during the study period. General physical examination and local examination of the neck of all the patients was also done at the time of admission. Preoperative PTH hormone and serum calcium levels estimation was done. Ultrasonography performed with neck extended in the supine position, with the thyroid gland as the reference was done. Minimal invasive parathryoidectomy was carried out. A 50% reduction in PTH level from baseline was used as an indication that the exploration was successful. Results: MIN invasive parathyroidectomy was done in 93.33 % of the cases while it was not done only in two cases. Neck exploration was required only in two cases while in remaining 28 cases, no neck exploration was required. Mean PTH levels pre-operatively, at 10 minutes, 30 minutes and 24 hours post-operatively were 613.5, 231.5, 102.3 and 101.2 respectively.Significant results were obtained while comparing the mean PTH levels at different time intervals. Conclusion: A targeted MIP guided by preoperative radiological localization and IOPTH can achieve an excellent operative success rate.