Journal of AdvancedMedical and Dental Sciences Research

Background: Osteoarthritis (OA) is the most prevalent musculoskeletal disorder worldwide and increasingly important in public health concern. The present study was conducted to compare the efficacy of tocotrienol and turmeric (curcuma longa) in knee osteoarthritis. Materials & Methods: 72 patients of knee osteoarthritis of both genders were divided into 4 groups. Group I- Diclofenac 50 mg, Group II- Diclofenac 50 mg + CL 500 mg, Group III- Diclofenac 50 mg + Tocotrienol 200 mg and Group IV- Diclofenac 50 mg + CL 500 mg + Tocotrienol 200 mg. Parameters such as knee pain by VAS and SOD were determined. Results: Grade 1 was seen in 10, 9, 7 and 6 and grade 2 in 8, 9, 11 and 12 in group I, II, III and IV respectively. VAS score 0 was 7.4, 14.2, 15.4 and 15.6, VAS 60 in 6.1, 10.6, 10.5 and 9.2, VAS 120 was 4.3, 7.1, 8.2 and 6.3 in group I, II, III and IV respectively. The difference was significant (P< 0.05). The mean SOD at 0 was 2.5, 2.4, 2.8 and 2.7 at SOD 0, 2.9, 3.2, 3.7 and 3.2 at SOD 60 and 3.1, 3.8, 3.9 and 3.7 at SOD 120. The difference was significant (P< 0.05). Conclusion: Combination of standard drug+ curcumin+ tocotrienol was found to be better than other regimen.