Journal of AdvancedMedical and Dental Sciences Research

Aim: To study the hepatic parameters in congestive heart failure patients. Methods: The prospective analytical study was conducted in the Department of General Medicine. Patients with heart failure all age and both sexes were included in this study. 100 patients with heart failure were included in this study. Various demographic parameters like age sex duration of disease were recorded on predesigned Performa. The hepatic biochemical parameters like serum bilirubin (direct, indirect and total), serum AST and ALT, Serum alkaline phosphatase, Serum proteins and Prothrombin time were estimated. Results: Mean age of patient was 57.87±9.69 years. Number of patients below than 30 years was 6 (6%), from 30 to 50 years were 17(17%). Maximum number of patients was from above 50 years of age that is 77 (77%). There was male predominance (79/21). As per NYSA classification maximum number of cases were class II (40%) followed by class III (30%). Percentage of patients with class I were 20% and class IV were 10%. Serum bilirubin was 3.65±1.74 mg/dl in class IV and least in class I that is 1.16±0.54 mg/dl. Serum AST was highest in class IV 159.24±21.26 IU and least in class I that is 38.88±10.87 IU (p=0.001). Serum ALT was highest in class IV 187.39±31.98 IU and least in class I that is 34.24±10.69 (p=0.001). Serum ALP was highest in class IV 59.89±14.59 IU and least in class I that is 40.27±8.69 (p=0.04). Serum total protein (g/dl) was decreased as the heart failure progressed least in class IV 3.69±1.84 g/dl and highest in class I that is 6.88.10±1.58 gm/dl (p=0.04). Serum albumin (g/dl) was least in class IV 2.86±0.85 g/dl and highest in class I that is 3.55±0.89 gm/dl (p=0.03). Prothrombin time (sec) was highest in class IV 21.65±5.85 sec and least in class I that is 11.88±3.78 sec (p=0.01). Conclusion: We conclude that Congested hepatomegaly was common presentation jaundice and ascites was also common. Change in biochemical parameters was increased with severity and duration of heart disease.