Journal of AdvancedMedical and Dental Sciences Research

Background: There is high rates of dyslipidaemia among diabetic patients which is believed to be one of the major factors accounting for the high percentage of deaths among diabetics due to cardiovascular disease. The present study compared rosuvastatin, pravastatin and atorvastatin among dyslipidemic diabetic patients. Materials & Methods: 60 type II diabetic patients of both genders were grouped. Group I patients received 20 mg atorvastatin, group II received 20 mg rosuvastatin and group II received 20 mg pravastatin. Lipid profile such as LDL, HDL, TG, total cholesterol level was measured. Results: The mean % reduction LDL was -19.2 in group I, -29.4 in group II and -10.2 in group III, % reduction TG was -19.8 in group I, -25.4 in group II and -12.4 in group III, % reduction TC was -13.6 in group I, -22.6 in group II and -15.7 in group III and % increase HDL was -5.2 in group I, -4.6 in group II and -5.9 in group III. The difference was significant (P< 0.05). Conclusion: The rosuvastatin was the most effective statin at reducing LDL-C as compared to atorvastatin and pravastatin.