Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to compare the efficacy of MgSO4 and Nifedipine in pre- term labour. Materials & Methods: The present study was conducted on 70 patients in active preterm labor who were 24 weeks to 33 weeks and 6 days gestation. Patients were divided into 2 groups. Group I received magnesium sulfate and group II patients received nifedipine. In both groups, primary outcome and secondary outcome was recorded. Adverse effects were also recorded. Results: There were no differences between the groups in the proportion of patients who delivered within 48 hours, gestational age at delivery and delivery before 37 weeks (P< 0.05). The mean birth weight of babies in group I was 2510 grams and in group II was 2630 grams, respiratory distress syndrome (RDS) was seen in 8 in group I and 7 in group II, intraventricular hemorrhage (IVH) was seen in 1 in group I only and necrotizing enterocolitis (NEC) was not seen in any group, sepsis was seen in 2 in group I and 1 I group II, death 1 in group I only. Neonatal intensive care unit admission (NICU) was seen in 18 in group I and 13 in group II and mean days in NICU was 8.2 days in group I and 4.1 days in group II. Conclusion: Authors found that more patients in group I achieved the primary outcome of prevention of preterm delivery for 48 hours with uterine quiescence as compared to group II. Nifedipine was associated with fewer maternal adverse effects as compared to magnesium sulphate.