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Volume 6 Issue 12 (December, 2018)

Original Articles

Assessment of prevalence of non-alcoholic fatty liver disease in hypothyroid patients
Dr. Parag Sharma

Background:Non-alcoholic fatty liver disease (NAFLD) means accumulation of fat mainly triglycerides exceeding 5% of liver weight, affecting approximately 20% of population in developed countries.The present study was conducted to assess prevalence of non-alcoholic fatty liver disease in hypothyroid patients. Materials & Methods:96 cases of hypothyroidism of both genderswere enrolled.Staging and grading were performed according to the Brunt et al scoring. The size, the presence of focal lesions, hepatic steatosis was recorded. Serum ferritin was measured by ELISA. Results: Out of 96 patients, males were 36 and females were 60.TSH (IU/ml) level <5 was seen in 5, 6-20 in 9, 21-35 in11, 36-50 in 35, 50-65 in 16 and >65 in 20 patients. Fatty liver grade I was seen in 12, II in 20 and III in 8 patients. Serum ferritin level in grade I males was 162.5 and in females was 172.6. in grade II males was 511.4 and in females was 236.8 and grade III was seen in 583.2 and in female was 378.4. The difference was significant (P< 0.05). Conclusion: Serum ferritin could help in predicting the natural history of NAFLD in hypothyroidism patients. The serum ferritin levels were found to be increased in patients of fatty liver with hypothyroidism.

 
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