Journal of AdvancedMedical and Dental Sciences Research

Background: Endotracheal extubation is the translaryngeal removal of a tube from the trachea via the nose or mouth. Esmolol is used in various settings including urgent care, perioperatively, and postoperatively Diltiazem has been used extensively to maintain perioperative haemodynamic stability. Hence; under the light of above mentioned data, the present study was planned for assessing and comparing the effect of diltiazem and esmolol in attenuating the cardiovascular responses to tracheal extubation. Materials & methods: 60 patients with ASA physical status I or II undergoing elective surgery under general anaesthesia with endotracheal intubation were randomly divided into 2 groups using random number tables. The groups were organized as follows: Diltiazem group (Group 1, n=30): 0.1mg/kg of Diltiazem to be diluted in NS till 10 cc, and Esmolol group (Group 2, n=30): 1mg/kg of Esmolol to be diluted in NS to make 10 cc. A Performa was made and alterations in the heart rate were recorded. All the results were recorded and analyzed using SPSS software. Mann-Whitney U test was used for evaluation of level of significance. Results: Mean heart rate in the Group 2 was significantly lower in comparison to Group 1 at extubation, 1 minute after extubation, 3 minutes after extubation, 5 minutes after extubation, 10 minutes after extubation and 15 minutes after extubation. Hypotension was seen in 13.33 percent of the patients of the Group 1 while it was seen in 3.33 percent of the patients of the Group 2. Bradycardia was seen in 3.33 percent of the patients of group 2. Conclusion: In attenuating heart rate changes, esmolol is more effective than diltiazem during tracheal extubation.