Journal of AdvancedMedical and Dental Sciences Research

Background: Cervical cancer is the fourth-most common cause of cancer in the women, worldwide and its incidence in young women is increasing year by year. Tumor protein P63 also known as transformation-related protein that in humans is encoded by the TP63gene. Hence; the present study was undertaken for assessing the expression of p63 among cervical carcinoma patients. Materials & methods: The study was conducted on 30 histopathologicaly proven cases of cervical carcinoma diagnosed in Department of Pathology. Detailed clinical data of the patient were recorded as per proforma attached. Tissue blocks were prepared from samples of cervical lesions obtained at department of pathology that were sent for hisopathological examination for doing IHC study. For IHC study expression of p63 was studied Histopathological examination of the tissues obtained was done after processing them to prepare paraffin blocks. Blocks were cut and stained with Haematoxylin and Eosin stain and studied under light microscope for classification and histopathological grading. Immunohistochemistry of the samples was done for p63. Results: In the well-differentiated carcinoma patients, mild, moderate and strong expression of p63 was seen in 30 percent, 50 percent and 20 percent of the patients respectively. In the moderately-differentiated carcinoma patients, mild, moderate and strong expression of p63 was seen in 0 percent, 70 percent and 30 percent of the patients respectively. In the poor-differentiated carcinoma patients, mild, moderate and strong expression of p63 was seen in 0 percent, 0 percent and 100 percent of the patients respectively. Significant results were obtained while comparing the expression of p63 among different grades of cervical carcinoma. Conclusion: Expression of p63 is significantly altered in cervical carcinoma patients.