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Volume 7 Issue 8 (August, 2019)

Original Articles

An Association of total plasma homocysteine levels in hypothyroid patients
Chandra Shekhar Baid, Mahaveer Singh

Introduction: This meta-analysis was to elucidate plasma Hcy levels in patients with hypothyroidism, and to evaluate the effect of L-T4 therapy on plasma Hcy levels in patients with hypothyroidism. Materials and Methods: Thyroid profile- Total T3 and Total T4 was measured by Competitive Enzyme Linked Immunosorbent Assay, and TSH by Non-competitive Sandwich ELISA.Total plasma Homocysteine was measured by Competitive Enzyme linked Immunosorbent Assay by using Axis-shield Homocysteine EIA kit. A statistical analysis was done by using ANOVA to compare TSH, Homocysteine levels between three groups. Correlation of TSH with Homocysteine was done by using Pearson Correlation Coefficient. SHO is characterized by a serum TSH above the upper reference limit in combination with a normal FT4. Results: Highly significant difference was observed between the study groups in Body mass index and TSH with the p value < 0.001. There was significant difference in total plasma homocysteine level between study groups with the p value 0.005. Conclusion: We identified an association between hyperhomocysteinemia and FT4 in a group of euthyroid type 2 diabetes patients for the first time. Keywords: plasma homocysteine, hypothyroid, Thyroid profile.

 
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