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Volume 4 Issue 5 (September - October, 2016)

Original Articles

Evaluation of Thyroid Function in Patients with Chronic Renal Disease
Chandra Shekhar Baid

The functions of thyroid and kidney are interrelated because thyroid hormones are essential for growth and development of the kidney and for maintaining electrolyte and water homeostasis. On the other hand, kidney plays an important role in the metabolism, degradation and excretion of thyroid hormone. Thus, aim of this study is to compare the mean value of thyroid hormones in chronic kidney disease patient as compare to normal individuals. Material and method: A total of 150 participants were taken in this study. Out of which 75 were normal age matching control and 75 were known cases of chronic renal disease. Morning sample after 12 hours of fasting were drawn aseptically and serum TSH, FT3 and serum FT4 were analysed by using fully automated analyser and test value were recorded for further analysis. Statistical analysis of collected data has been determined by using SPSS (16.0). The results of laboratory tests of this study have been summarized as mean ± standard deviation. Result: According to the result of this study we can state TSH not usually influences the activity of FT4 statistically. But the value of FT3 is highly influence in cases and control by TSH. So, monitoring of these hormones and its treatment can influence the health of an individual. Conclusions: The present study finds thyroid dysfunction to be very common in CKD patients and reveals the significant association between CKD progression and thyroid dysfunction and mean of FT3 increases as TSH decreases significantly in cases as compared to controls. Keywords: Hypothyroidism, CKD, TSH, FT4, FT3

 
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