Journal of AdvancedMedical and Dental Sciences Research

Introduction: Screening of pre-malignant lesions of gall bladder is mandatory for early detection of disease and presence of suspicious lesion. The aim of our study was to assess the demographic and clinicopathological outline of the patients with gallbladder cancer. Materials and Methods: The demographic characteristics include age, sex, and socioeconomic status. Nonclinical risk factor includes parity, obesity, menstrual status, and use of contraceptive pills among premenopausal female. Diagnosis of gallstone, serum level of triglycerides, total cholesterol, and diabetes were taken as clinical risk factor. Result: Nearly 44(88%) patients in study group had advanced disease (Stage 3 or 4) at presentation. The pain was the most common symptom, present in all patients studied. Jaundice was present in half of the patients (56%). Interventional biliary drainage was required in 16% of the patients. Poorly differentiated adenocarcinoma was the predominant histology seen (44%). Liver, nonregional lymph nodes, and omentum were the common sites of metastasis. Majority of the stage 4 patients had metastases to at least two organs (68%). Conclusion: Factors like better hygiene and water supply to prevent typhoid carriers, prevention of malnutrition, and early intervention for cholelithiasis are important. Keywords: cholelithiasis, Gallbladder cancer, malignancy.