Journal of AdvancedMedical and Dental Sciences Research

Aim: The aim of the present study was to evaluate clinically the effectiveness of various treatment modalities in the management of oral submucous fibrosis. Materials and Methods; Forty five patients were in the study, based on habitual history and clinical findings they were diagnosed to have oral submucous fibrosis. Three groups were made after randomization, i.e. Group A: Physiotherapy group (Control group), Group B: Lycopene group, Group C: Injection Dexamethasone with hyaluronidase group. Symptom severity was done by VAS scoring system viz burning sensation/pain in the patients, Patient satisfaction was assessed. Patients’ maximum mouth opening was measured at baseline, 1st month and 3rd month. Results; The more number of fairly unsatisfied patients were there in Group A (Physiotherapy group). VAS score in the study groups did not have statistical significance differences at baseline. Study subjects with no pain were more in group C followed by group B on 3rd month and there was a statistically significant difference found at 1st and 3rd month between the groups. In group C, the mouth opening had improved more in 1st month and 3rd month (24.28±0.36, 27.84±0.09) followed by group B (23.98±0.13, 25.15±1.29) and group A (20.64±1.24, 22.12±1.03) respectively. On 1st and 3rd month, statistically significant difference was observed between the study groups.(Table 3). Conclusion; This study concludes that the treatment with Dexamethasone with Hyaluronidase group showed better results in improvement of mouth opening in oral submucous fibrosis patients compared to Lycopene and Physiotherapy groups. Keywords: Antioxidants, Dexamethasone, Hyaluronidase, Lycopene, Oral submucous fibrosis.