Journal of AdvancedMedical and Dental Sciences Research

UV radiation (UV) is classified as a complete carcinogen, because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. Skin cancer is the most common type of cancer in fair-skinned populations in many parts of the world. The incidence, morbidity and mortality rates of skin cancers are increasing and, therefore, pose a significant public health concern. Ultraviolet radiation (UVR) is the major etiologic agent in the development of skin cancers. UVR causes DNA damage and genetic mutations, which subsequently lead to skin cancer. A clearer understanding of UVR is crucial in the prevention of skin cancer. Several factors influence the amount of UVR reaching the earth’s surface, including ozone depletion, UV light elevation, latitude, altitude, and weather conditions. The current treatment modalities utilizing UVR can also predispose to skin cancers. Unnecessary exposure to the sun and artificial UVR are important personal attributable risks.
Key words: Carcinogen, Ozone, Skin cancer, Ultraviolet radiation

Corresponding author: Dr. Devendra Parmar, Associate Professor, Department of Skin, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat- 370001.

This article may be cited as:  Parmar D, Shah J. Role of Ultraviolet Radiation in Skin Cancer:  A Review Article. J Adv Med Dent Scie Res 2015;3(4):83-85.