Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to compare mephentermine and norepinephrine in cesarean section. Materials & Methods: 84 females of American Society of Anaesthesiologists physical status (ASA)–ІІ and singleton term pregnancy posted for elective CS were randomly divided into 2 groups of 42 each. Group I received boluses of intravenous norepinephrine 8µg and group II received mephentermine 6 mg. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), Apgar score and maternal complications were analysed. Results: The mean systolic blood pressure was 124.2 mm Hg and 130.2 mm Hg in group I and II respectively, diastolic blood pressure was 82.4 mm Hg and 88.2 mm Hg in group I and II respectively, heart rate was 80.4 beats/minute and 86.4 beats per minute in group I and II respectively, duration of surgery was 46.2 minutes and 46.0 minutes in group I and II respectively, APGAR score at 1st minute was 7.82 and 7.64 in group I and II respectively, APGAR score at 7th minute was 9.41 and 9.45 in group I and II respectively. The difference was non- significant (p> 0.05). Common adverse events were nausea/ vomiting 9 in group I and 10 in group II, headache 7 in group I and 8 in group II, shivering 5 in group I and 4 in group II and hypertension 6 in group I and 7 in group II. The difference was non- significant (p> 0.05). Conclusion: Intravenous norepinephrine was better than mephentermine in cesarean section, however results can be comparable. Key words: Apgar score, Mephentermine, Norepinephrine.