Journal of AdvancedMedical and Dental Sciences Research

Background: Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) are the leading causes of cirrhosis and hepatocellular carcinoma, two conditions with increasing mortality and burden of disease especially in the developing countries. Since diabetes is another major concern in public health, it is very important to establish if chronic viral hepatitis is associated with an increased risk of diabetes prior to the development of end-stage liver disease. Aim of the study: To study seroprevalence of Hepatitis B and C in type 2 diabetes patients in a tertiary care. Materials and methods: For the study, we evaluated 50 patients with type II diabetes mellitus. The patients were evaluated on the basis of clinical, biochemical and ultrasonographic findings. We only selected patients who had at least one year of history of T2DM, and on anti-diabetic agents and or insulin therapy. Patients between the age of 25-70 years of age. We also selected 50 non-diabetic patients to compare the seroprevalence rates in patients without DM. A detailed history, anthropometry and clinical examination was done and recorded from all the patients. All patients in the study had undergone relevant investigations including complete blood count, blood sugar, liver function test, HBsAg, Anti HCV antibodies and Lipid Profile. Results: A total of 100 patients participated in the present study, 50 were diabetic and 50 were non-diabetic. Number of males in study group and control group was 29 and 28, respectively. The number of females in study group and control group was 21 and 22, respectively. The mean age was 39.68 years in study group and 34.68 years in control group. It was observed that mean FBG was more in study group as compared to control group. Furthermore, 12 patients in study group were tested postive for HbsAg and 10 patients in control group tested postive. In diabetic group, 11 patients tested postive for anti-HCV and 3 patients in control group tested postive for anti-HCV. The results were statisticlaly significant for FBG and anti-HCV results. Conclusion: Within the limitations of the present study, it can be concluded that the rate of seroprevalence for hepatitis B is non-significant between diabetic and non-diabetic patients. On the contrary, HCV seroprevalence has statistically significance between diabetic and non-diabetic patients. Keywords: hepatitis B, hepatitis C, type 2 diabetes mellitus.