Journal of AdvancedMedical and Dental Sciences Research

Background: Oral submucous fibrosis is a precancerous condition with 7-12% malignant potential rate. Present study was conducted with aim to elucidate the role of lycopene in treatment of oral submucous fibrosis. Material and methods: The study group included 72 patients with OSMF. Out of 72, 24 patients were given lycopene, other 24 with lycopene + Vitamin E and remaining 24 were on placebo drug. Lycopene group patients received 8 mg Lycored TM per day in two divided doses of 4 mg each, second group with LYC-O-MATO soft gels while placebo group patients received placebo tablet twice a day. Patients were examined for changes in mouth opening and other clinical symptoms of OSMF during three months. Results: Lycopene in combination with vitamin E was found to be significantly efficacious in the improving signs and symptoms of OSMF. It was effective in reducing the objective signs of OSMF as demonstrated by the improved maximal mouth opening, and reduction in burning sensation, erosion/ ulceration. Conclusion: Lycopene in combination with vitamin E is a highly efficacious drug in the management of oral submucous fibrosis which is proven to be as safe and reliable treatment method.
Key words – Lycopene, Oral submucous fibrosis, Precancerous condition, Vitamin E.

Corresponding Author: Dr. Abhijit Nayak, Final year post graduate student, Department of Oral Medicine and Radiology, Vyas Dental College & Hospital, Jodhpur, Rajasthan, India.
E mail: abhijitnayakomr@gmail.com
This article may be cited as:   Nayak A, B Anitha, Bhattacharya A, Podder S. Efficacy of Lycopene in Combination with Vitamin E in Management of Oral Submucous Fibrosis - A Clinical Prospective Study. J Adv Med Dent Scie Res 2015;3(3):21-25.