Journal of AdvancedMedical and Dental Sciences Research

Background- Oral Squamous Cell Carcinoma is the 6th most common malignancy worldwide and 2nd most common malignancy in Indian population. Conventional pathologic tumour classifications have proved to be valuable indicators of prognosis, but do not take into account the individual biologic properties of a distinct tumour. cytometrically determined nuclear DNA content of tumor cells is suggested to be an additional objective parameter for their biologic behavior. AIM- The present study was aimed to analyze the prognostic value of DNA ploidy status in oral squamous cell carcinoma. Materials And Methods-DNA ploidy status of 43 formalin fixed paraffin embedded tissue samples of primary oral squamous cell carcinoma was evaluated using flow cytometry and was correlated with clinical staging and histological grading. Results- Overall incidence of aneuploidy was found to be 44.19%. Association of ploidy status with histopathological grade was statistically significant (p=0.001). Association of ploidy status with clinical stages was not found to be statistically significant (p=0.078) Conclusion-DNA ploidy measurement is a valuable adjunct to clinical and histopathological assessment of oral squamous cell carcinoma.
Key words- DNA ploidy; Flow cytometry; Oral squmous cell carcinoma

Corresponding Author: Dr. Neelu Nagpal, Senior Lecturer, Department of Oral and Maxillofacial Pathology, RKDF Dental College and Research Centre, NH – 12 Bhopal, Madhya Pradesh, India – 462026, E-mail: drneelu.nagpal@gmail.com

This article may be cited as:   Joshi PS, MC Prashant, Nagpal N, Patil AA, Mathur V, Ahuja R. DNA Ploidy Analysis Of Oral Squamous Cell Carcinoma - A Retrospective Flow Cytometric Study. J Adv Med Dent Scie Res 2015;3(3):16-20.