Journal of AdvancedMedical and Dental Sciences Research

Background: Type 2 diabetes mellitus and hypothyroidism are the most prevalent metabolic disorders. Coexistence of thyroid disease and diabetes mellitus is a well-recognized positive association. The effect of thyroid dysfunction on glucose metabolism in non-diabetic patients is a thrust area of research. Present study was conducted to study the levels of glycosylated haemoglobin (HbA1c) in non-diabetic patients with hypothyroidism. Material and methods: This case-control study was conducted on 100 subjects. A total of 50 subjects with hypothyroidism and without diabetes were selected as cases and another 50 age and sex matched normal healthy individuals were selected as controls. An independent t-test was applied to find out the significance of the statistical difference amongst various parameters in the case and the control groups. Regression analysis was done for correlation between serum TSH, T3, T4 and HbA1c. Results: It was found that there was a positive correlation between the levels of serum TSH (μU/L) and HbA1c (%) in all the participants of the study by Pearson’s correlation coefficient. Conclusion: HbA1c levels were increased in hypothyroid patients. The present study suggests that HbA1c levels should be interpreted with caution in hypothyroid patients. Keywords: diabetes mellitus, HbA1c, hypothyroidism, TSH