Volume 6 Issue 8 (August, 2018)

Original Articles

Assessment of endothelial changes in patients with Non-alcoholic fatty liver disease
Dr. Sumit Saraswat

Background: Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver condition. This study aimed at assessing endothelial changes in patients with Nonalcoholic fatty liver disease. Materials & Methods: The present study was conducted on 40 non-alcoholic fatty liver disease subjects and 40 healthy subjects (controls) without any fatty liver disease. Brachial artery diameter and its changes was determined by using a high resolution B mode ultrasonography system. Flow mediated vasodilatation (FMD) was calculated using the following formula: FMD = (d2-d1)/d1 x 100, where d2= Brachial artery diameter at 5 min post deflation and d1 = Base line brachial artery diameter. Results: Group I had 22 males and 18 females and group II had 23 males and 17 females. The mean DI in group I was 3.82 mm and in group II was 3.70 mm. The difference was non- significant (p> 0.05). The mean D2 in group I was 4.02 mm and I control was 4.19 mm. The difference was significant (p< 0.05). The mean flow mediated vasodilatation in group I was 0.17 and in group II was 0.42. The difference was significant (p< 0.05). Conclusion: Authors found that Non-alcoholic fatty liver disease (NAFLD) is a growing global health problem. There was lower FMD in brachial artery in patients with non-alcoholic fatty liver disease. Key words: Brachial artery, Non-alcoholic fatty liver disease, Vasodilatation

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