Journal of AdvancedMedical and Dental Sciences Research

Background: Vitamin-D plays a pivotal role in regulating homeostasis of bone and mineral metabolism but it also has non skeletal actions since vitamin-D receptors are present in various tissues including the brain, breast, prostate, pancreas, colon and immune cells. Biological functions of vitamin-D includes bone metabolism, immune response modulation and regulation of cell differentiation and cell proliferation. It is believed that vitamin-D might play role in the risk of cardio metabolic outcomes, including diabetes mellitus, hypertension and cardiovascular disease. The magnitude of type 2 diabetes worldwide is on the rise and is either due to lack of insulin or due to inadequate insulin action following increase in insulin resistance. Therefore, it is imperative to think that vitamin-D deficiency might be playing a role in insulin resistance leading to diabetes mellitus. The present study has been planned to study the association of Vitamin-D and insulin resistance in subjects with prediabetes. Materials & Methods: This observational cross sectional study was conducted at Sir Sunderlal Hospital, BHU, Varanasi. A total of 60 subjects with IFG (fasting blood sugar of 100-125 mg/dl) and/or IGT (2 hr. post prandial blood sugar of 141- 199 mg/dl) or with HbA1c of 5.7 - 6.4, who fulfilled the inclusion and exclusion criteria were included. Fasting blood sugar, 2-hour post prandial blood sugar, HbA1C, Ser. Vitamin-D and fasting insulin were estimated. Insulin resistance was determined by HOMA-IR. Statistical analysis was done by Chi square test, Student t test, Wilcoxon signed-rank test. P value of <0.05 was taken to be significant. Results: Vitamin-D deficiency was found in almost 40% of the study subjects. There was a statistically significant difference and negative correlation between HOMA-IR and HDL of the subjects with vitamin-D deficiency, insufficiency as well as in the sufficiency group (p=0.009 and 0.028 respectively). Conclusion: Our study results indicate that low vitamin-D levels are associated with prediabetes. Interventional studies on large sample can help in determining if vitamin-D supplementation can have a beneficial effect on the progression of prediabetes to diabetes. Key words: prediabetes, insulin resistance, vitamin-D, diabetes mellitus