Journal of AdvancedMedical and Dental Sciences Research

Background: Non alcoholic fatty liver disease (NAFLD) is fast attaining the status of being the most common disease throughout the world. The present study was conducted to evaluate the association of fatty liver severity and endothelial function in Non-Alcoholic Fatty Liver Disease (NAFLD) patients. Materials & Methods: The present study was conducted on 60 non-alcoholic fatty liver disease subjects (group I) and 60 healthy volunteers (group II) without any fatty liver disease. Biochemical tests including liver function tests were performed. These include serum bilirubin, total serum protein, serum albumin, serum globulin, aspartate aminotranferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and prothrombin index (PTI). Brachial artery diameter and its changes were determined by using a high resolution B mode ultrasonography system. Flow mediated vasodilatation (FMD) was also done. Results: There were 36 male and 24 female in group I and 32 male and 28 female in group II. The mean fasting blood glucose level in group I was 98.04 mg/dl and in groupie was 95.18 mg/dl. The mean random blood glucose level in group I was 118.9 mg/dl and in group II was 112.5 mg/dl. The mean D1 in group I was 3.67 mm and in group II was 3.78 mm. The difference was non- significant (p> 0.05). The mean D2 in group I was 4.03 mm and in group II was 4.34 mm. The mean flow mediated vasodilatation in group I was 0.16 and in group II was 0.41. The difference was significant (p< 0.05). Conclusion: The mean FMD in brachial artery in patients with non-alcoholic fatty liver disease is below normal range. Key words: Aspartate aminotranferase, Fatty liver disease, Flow mediated vasodilatation