Journal of AdvancedMedical and Dental Sciences Research

Background: Tinea literally refers to insect larva (cloth moth) that was felt by Romans to be the cause of infection. The present study compared Terbinafine and Itraconazole in Dermatophytic infections. Materials & Methods: The present study was conducted on 60 patients with Dermatophytoses. Patients were divided into 2 groups. Group I received terbinafine 500 mg daily for 4 weeks and group II received itraconazole 200 mg for 4 weeks daily. Patients were followed up after 2 weeks and 4 weeks. At each visit, clinical response was noted including pruritus, erythema and scaling. These were rated as clinical score 0–3, 0 – absent, 1 – mild, 2 – moderate, and 3 – severe. Results: There was significant improvement in scaling, pruritus and erythema score in both groups (P< 0.05) recorded at baseline, 2 weeks and 4 weeks. In group I, 8% and in group II 15% showed complete heal of lesions while 52% in group I and 64% in group II showed marked improvement, 7% in group I and 6% in group II had >50% of residual lesion, 20% in group I and 10% in group II had no change and 13% in group I and 5% in group II had worse lesion. The difference was significant (P< 0.05). Conclusion: Authors found that Itraconazole and terbinafine are equally effective and safe in the treatment of dermatophyes. Key words: Dermatophyes, Itraconazole, terbinafine