Journal of AdvancedMedical and Dental Sciences Research

Background: The goal of inducing anaesthesia with minimum significant side effects continues to occupy the minds of anaesthesiologist. Etomidate and propofol are two ultra-short-acting sedative agents thought to provide these characteristics. Hence; the present study was undertaken for comparing the hemodynamic changes and complications occurring with Propofol and etomidate during general anesthesia. Materials and methods: A total of 100 patients were enrolled in the present study and were broadly divided into two study groups with 50 patients in each group: Propofol group and Etomidate group.Patients who were scheduled to undergo elective surgical procedure under general anesthesia with endotracheal intubation were enrolled. After enrolling the patients and obtaining their informed consent, complete demographic and clinical details of all the patients was obtained. Preoperative hemodynamic assessment of all the patients was done. Premedication of all the patients was done with alprazolam 0.25 mg and ranitidine 150 mg one night before the surgery. Anesthesia was given to all the patients according to their respective groups. Pain on injection and myoclonic movements were recorded, if any at induction. All the hemodynamic parameter was recorded during the surgery procedure. Results: In comparison to etomidate, propofol showed significant variation in MAP at different time intervals (p- value < 0.05).  In comparison to etomidate, propofol showed significant variation in heart rate at the time of induction of anesthesia (p- value < 0.05). Significant higher incidence of pain on injection and myoclonic movements was seen among patients of the Propofol group in comparison to the patients of the Etomidate group (P- value < 0.05). Conclusion: In terms of hemodynamic stability and pain of injection, the efficacy of etomidate as an anesthetic agent is superior in comparison to propofol.
Keywords: Hernia, Inguinal, Repair

Received: 19 May, 2019                            Revised:  10 July 2019                              Accepted: 11 July 2019

Corresponding author: Dr. Parag Agarwal, Associate Professor, Department of Anaesthesia, Autonomous state Medical College, Ayodhya, India

This article may be cited as: Singh BN, Agarwal P. Hemodynamic changes and complications occurring with Propofol and etomidate during general anesthesia. J Adv Med Dent Scie Res 2019;7(8): 158-161.