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Volume 7 Issue 4 (April, 2019)

Original Articles

A Prospectively comparative study to evaluate urine protein/creatinine ratio in Hypertensive disorders of Pregnancy as an alternative to 24 hour method
Jagdeep Kaur

Background: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming. As an alternative, random spot sampling for a urine protein to creatinine (P/C) ratio has been investigated. Objectives: To prospectively compare random urine protein/creatinine ratio in Hypertensive disorders of Pregnancy. Methods: A prospective study was carried on all patients admitted with suspected / Diagnosed Hypertensive disorders of Pregnancy in Northern Railways Central Hospital, between May 2008 to June 2009 . After 24 hour urine for Protein evaluation, a random sample for Protein/creatinine ratio was taken from all patients.Urine protein was measured by Biuret Method and  urine creatinine by Jaffey’s method . Significant Proteinuria was taken as > 300 mg/ 24 hours by 24 hour method and > 0.3 mg/mg by Protein/creatinine ratio. Both 24 hour protein and protein/creatinine ratio were compared using statistical  analysis 24 hour protein was taken as gold standard for comparison. Results: 90 patients were enrolled in the study. Out of 90 patients , 30 patients had significant proteinuria. Mean Age of the study group was 25 years .53.3 % of patients were nullipara. Mean value of 24 hour protein was 0.477 g/day and mean value of protein-creatinine ratio was 0.489 mg/mg. The random protein-reatinine ratio showed a good correlation with 24 hour protein with a 90 % sensitivity and a specificity of 86.67 %. The False Positive rate and the Negative Positive rate of random protein-creatinine ratio  was  13.33 % and 10 % respectively. Conclusion:  Protein-creatinine ratio can emerge as a good alternative to 24 hour protein in proteinuria evaluation.
Key words: Protein/creatinine ratio, proteinuria, pre-eclampsia.

Received: 18 November 2018                                  Revised: 12 February 2019                            Accepted: 14 February 2019

Corresponding author: Dr. Jagdeep Kaur, Medical officer Gynaecology, Civil Hospital Mukerian, Punjab, India

This article may be cited as: Kaur J. A Prospectively comparative study to evaluate urine protein/creatinine ratio in Hypertensive disorders of Pregnancy as an alternative to 24 hour method. J Adv Med Dent Scie Res 2019;7(4):133-137.

 
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