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Volume 7 Issue 4 (April, 2019)

Original Articles

Ki-67 as a prognostic marker in patients with Primary Breast Cancer
Siddharth Gangwar, Vijai Singh

Introduction: Breast cancer is amongst most common cancer in females and is 2nd most common reason of death in patients with
cancer in the world. Cell proliferation has an important function in the clinical behavior of invasive breast cancer. We aimed to
assess the status of Ki-67 in patients with primary breast cancer and evaluated the association of this tumor marker with other
clinico-pathologic and prognostic factors. Materials and Method: The current study consisted of 50 patients with primary breast
cancer admitted to the surgical ward of Hind Institute of Medical Sciences Safedabad, Barabanki. Evaluation of Ki-67 IHC slides
were done and reported. Among 50 patients, 16developed grade 2 tumors, and21 were below 50 years age. 29 cases were Ki-67
positive with more than 1% tumor nuclei stained, and 15 cases had tumors with more than 15% of Ki-67 expression. Results: There
was no significant correlation between Ki-67 and patient's age, tumor size and grade however and there was a marginally significant
relationship between lymph node status and Ki-67 expression. Conclusion: A reliable estimation of different prognostic factors in
breast cancer patients is required for the selection of an optimal therapeutic strategy. The attention has been focused on the markers
of tumor biology.
Key words: Breast Cancer, Grade, Lymph Node, Prognosis, Tumor Markers.
Received: 10 February, 2019 Revised: 27 March, 2019 Accepted: 29 March, 2019
Corresponding author: Dr. (Col.) Vijai Singh, Associate Professor, Department of Pathology, Hind Institute of
Medical Sciences, Safedabad, Barabanki, U.P., India
This article may be cited as: Gangwar S, Singh V. Ki-67 as a prognostic marker in patients with Primary Breast
Cancer. J Adv Med Dent Scie Res 2019;7(4): 125-128.

 
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