Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to assess correlation of tumor grading and perineural invasion with metastasis. Materials & Methods: The present study was conducted on 64 cases of both genders who were clinically and histopathologically diagnosed with oral squamous cell carcinoma. Incisional biopsy was taken for differentiation of the tumour. Clinical and radiological examination of the tumour regarding nodal involvement and metastasis was done and clinical TNM staging was noted. Assessment of perineural invasion was done. Results: Out of 64 patients, males were 41 and females were 23. Out of 64 cases, 34 (53%) had well differentiation, 24 (37.5%) had moderately differentiation and 6 (9.5%) had poorly differentiation. The difference was significant (P< 0.05). Maximum lymph node metastasis was seen in poorly differentiated squamous cell carcinoma (67%) followed by moderately differentiation squamous cell carcinoma (33.3%) and well differentiation squamous cell carcinoma (26.5%). The difference was non- significant (P< 0.17). 61% had positive perineural invasion, out of which 53.8% had positive lymph node metastasis. 39% had no perineural invasion and none had positive lymph node metastasis. The difference was significant (P< 0.05). Conclusion: Maximum lymph node metastasis was seen in poorly differentiated squamous cell carcinoma. There was positive correlation of perineural invasion (PNI) to lymph node metastasis.
Key words: Lymph node metastasis, Squamous cell carcinoma, Tumour.

Received: 8 February, 2019                             Revised: 27 March, 2019                               Accepted: 28 March, 2019

Corresponding author: Dr. Mahesh Melkundi, Professor, Dept of Oral Pathology, College of Dental. Sciences, Rau, Indore, MP, India

This article may be cited as: Mengi R, Bhagwat P, Premlata,  Das R, Melkundi M. Correlation of Tumor Grading and Perineural Invasion with Metastasis- A Clinical Study. J Adv Med Dent Scie Res 2019;7(4): 38-41.