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Volume 4 Issue 4 (July - August, 2016)

Original Articles

Cost effectiveness and anti-hypertensive efficacy of Metoprolol and Nebivolol - A Comparative Clinical Study
Siddharth Sonkar

Background: Hypertension is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. The present study was conducted to compare metoprolol and nebivolol in management of hypertension. Materials & Methods: The present study was conducted on 128 patients (males- 64, females- 64) age ranged between 18-60 years. They were divided into 2 groups of 64 patients each. Group I (32) received 10 mg nebivolol and in group II received 25 mg metoprolol. All were recalled to record blood pressure on day 1, day 25 and day 45.  Results: Mean age ±S.D (years) in group I was 46± 5.5 and in group II was 44± 5.6. BMI (Mean± S.D) (Kg/m2) in group I was 24.2± 2.6 and in group II was 26.2± 2.6. The difference was non- significant (P> 0.05). In group I, the mean SBP ±SD was 160.4± 4.6, on 25th day was 148.2± 3.4 and on 45th day was 140.4 ± 2.2. In group II, the mean SBP ±SD was 162.1± 4.0, on 25th day was 150.2± 4.2 and on 45th day was 138.2 ± 2.4. The difference was significant within the group (P< 0.05) whereas on comparison between the both groups, the difference was non- significant (P> 0.05).Conclusion: Both nebivolol and metoprolol found to have comparable effectiveness in patients with hypertension.
Key words: Hypertension, Metoprolol, Nebivolol
Corresponding author: Dr. Siddharth Sonkar, Assistant Professor, Department of Medicine, Prasad Institute of Medical Sciences Lucknow, Uttar Pradesh, India-
This article may be cited as:  Sonkar S. Cost effectiveness and anti-hypertensive efficacy of Metoprolol and Nebivolol - A Comparative Clinical Study. J Adv Med Dent Scie Res 2015;4(4):210-213.

 
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