Tumour microenvironment (TME) is a complex tissue environment in and around the tumour cells which includes extra cellular matrix, cancer associated fibroblast, blood vessels, immune cells, etc. tumour microenvironment plays a vital role in progression, metastasis and resistance to immune cells and anti-cancer therapy. Tumour microenvironment contains altered stromal and immune cells, also signals the tumour to progress very efficiently. Recent studies suggest targeting the altered molecules giving better prognosis. The purpose of this review is highlighting the molecular events taking place in tumour microenvironment which is being initiated and progressed by altered cell signals. The better understanding of tumour microenvironment in oral squamous cell carcinoma will give improved and combined anticancer therapy, to which may increase the survival rate of OSCC patients.
Key words: Oral Squamous Cell Carcinoma, Tumor Micro Environment , Cancer Associated Fibroblast , Angiogenesis, Hypoxia.