Journal of AdvancedMedical and Dental Sciences Research

Aim: The aim of the present study was to determine the effect of two different modalities on the management of oral submucous fibrosis. Materials and methods: The present study was conducted in the department of dentistry of the institute during a period of 6 months. All the subjects were followed for a period of 12 weeks and interincisal opening was measured. All the data was arranged in a tabulated form and analyzed using SPSS software. Results: The present study enrolled 100 subjects, out of which 50 were present in group 1 and 50 in group 2. There were majority of males in the study i.e. 60 were males and rest females. The mean age of the subjects was 36.59+/- 5.24 years. There were 56% (n=28) subjects in group I and 84% (n=42) subjects in Group 2 with grade III OSMF. There were 16% subjects in group 1 and 4% subjects in group 2 with 10-14 mm opening. There were 24% subjects in group 1 and 16% subjects in group 2 with 15-19 mm opening. Conclusion: In our study, the use of colchicine bought improvement in the patient’s clinical conditions and more studies should be undertaken to determine the exact usefulness of colchicine. Key words: Colchicine, Fibrosis, Hematoxylin.