Journal of AdvancedMedical and Dental Sciences Research

Background: Diabetes Mellitus is a disorder caused by the total (or relative) absence of insulin, which manifests clinically as an elevated blood glucose. This study was undertaken to determine the insulin resistance and urinary pH in offspring of diabetic parents. Materials & Methods: The present study was conducted in the department of Physiology. It comprised of 80 subjects of both genders. All were divided into 2 groups. Group I had those who had parental history of type II DM and group II was control group. Serum glucose levels were determined by the glucose oxidase method. Serum insulin concentration was determined by ELISA using commercial kits. Fasting glucose and fasting insulin levels were used to measure homeostasis model assessment of insulin resistance (HOMA-IR) index. Results: Out of 80 subjects, in group I, males were 22 and females were 18. In group II, males were 25 and females were 15. The difference was non- significant (P> 0.05). Fasting glucose (mmol/lt) in group I was 4.72± 0.62 and in group II was 4.62± 0.58. Fasting Insulin (ìIU/ml) in group I was 12.6± 5.68 and in group II was 10.4± 6.22. HOMA- IR in group I was 2.58± 1.21 and in group II was 2.08± 1.42. Urine pH in group I was 6.62± 1.2 and in group II was 6.50± 1.7. The difference was non- significant (P> 0.05). Conclusion: Author concluded that DM is a group of disorder having high mortality and morbidity. Insulin resistance and urinary pH as predictors of type2 diabetes is needed to be studied further. Key words: Diabetes mellitus, Insulin, Urine.