Journal of AdvancedMedical and Dental Sciences Research

Background:Diabetes conceivably predisposes to contrast induced nephropathy (CIN) principally through the amplification of these changes and the disruption of protective mechanisms, designed to maintain medullary oxygenation and to ameliorate oxidative stress. Hence; we planned the present study to evaluate the effect of contrast agents on renal functions based on serum creatinine and creatinine clearance in patients with diabetes.Materials & methods: The present study included assessment of effect of radio contrast enhanced computed tomography on the renal system in diabetic patients. We included a total of 60 patients and divided them broadly into two study groups with 30 patients in each group as follows:Group 1: All patients without a pre-existing renal disease non diabetic non hypertensive, and Group 2: Diabetic patients on treatment and not known hypertensive. Relative risk was calculated based on exposed as patients with CIN and non-exposed as without CIN. All the results were analyzed by SPSS software. Results:CIN was present in 13.3 percent of the control group population and 36.7 percent of the diabetic group population. Significant results were obtained while comparing the preoperative and postoperative creatinine values in both the study groups.Conclusion: Risk of development of contrast nephropathy is increased in diabetic patients. Key words: Diabetes, Radio contrast, Renal system