Journal of AdvancedMedical and Dental Sciences Research

Background: Chronic kidney disease encompasses a spectrum of different pathophysiologic processes associated with abnormal kidney functions and a progressive decline in glomerular filtration rate. The present study was planned to assess C reactive protein as an inflammatory marker in pre and post dialysis patients of chronic kidney disease with diabetes and hypertension. Materials & Methods: The study included one hundred patients attending OPD and indoor medical wards of Guru Nanak Dev Hospital, Amritsar. The patients were subjected to detailed history and clinical examination and other investigations. Information regarding age and sex distribution, clinical diagnosis was collected.  Biochemical testing for serum creatinine was performed in the Biochemistry department of Guru Nanak Dev Hospital. In a secondary analysis, C- reactive protein relation to albuminuria [defined as an urinary albumin-to-creatinine ratio (UACR) of > 30 mg/g on spot or 24-hour urine collection] was considered. Estimation of blood urea was done by Berthelot method. Serum creatinine was measured by Jaffe’s method The data was collected systematically and analysed statistically according to the standard statistical methods. Results: Mean pre-dialysis CRP was found to be 3.10 mg/L.Mean post-dialysis CRP was found to be 3.36 mg/L. Significant results were obtained while comparing the mean pre-dialysis and post-dialysis CRP levels. Conclusion: CRP value increases after dialysis, suggesting increased systemic inflammatory process which is a risk factor for cardiovascular morbidity and mortality.
Key Words: Chronic kidney disease, C Reactive proteins.

Received: 5 January  2019                                       Revised: 25 January 2019                              Accepted: 28 January 2019
Corresponding Author: Dr. Amit Kumar, Junior resident, Department of Medicine, GMC Amritsar, Punjab, India
This article may be cited as: Charan S, Kumar A, Oberoi KK, Aggarwal R, Singh A, Dubey GO. To study C reactive protein as an inflammatory marker in pre and post dialysis patients of chronic kidney disease with diabetes and hypertension. J Adv Med Dent Scie Res 2019;7(2):61-64.