Journal of AdvancedMedical and Dental Sciences Research

Background: Oral submucous fibrosis (OSMF) precancerous condition and is chronic, resistant disease characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues. The exact mechanism is not clear yet. Hence; we planned the present study to assess vitamin C levels in OSMF patients. Materials & methods:The present study was conducted with the aim of evaluating the serum vitamin C profile of patients with Oral submucous fibrosis. A total of 30 OSMF patients and 30 healthy controls were included in the present study. Complete demographic and clinical details of all the patients were collected. Diagnosis of OSMF was confirmed based on histopathologic and clinical signs and symptoms described previously in the literature.7 30 age and gender matched healthy subjects were included in the present study as healthy controls. Blood samples were collected from all the subjects and were sent to laboratory. Assessment of serum vitamin C levels was done using an auto-analyser.
Results: Mean vitamin C levels of the subjects of the control group was 1.05 mg/dl and was found to be significantly higher than that of the subjects of the study group (0.30 mg/dl). Conclusion:Vitamin C levels are significantly decreased in OSMF patients thus highlighting the amount of oxidative stress associated with the disease. 
Key words: Oral submucous fibrosis, Vitamin C

Corresponding author: Dr. Archana Kumari, Senior Resident (Dental), Sri Krishna Medical College, Muzaffarpur, Bihar, India

This article may be cited as: Kumari A, Roy S. Assessment of Serum vitamin C levels in Oral Submucous Fibrosis patients: A Case-Control Study. J Adv Med Dent Scie Res 2016;4(4):201-203.