Journal of AdvancedMedical and Dental Sciences Research

Background: Oral submucous fibrosis (OSF) is a premalignant disorder associated with the chewing of areca nut (betel nut). The present study was conducted to assess the effectiveness of Hyaluronidase OSMF. Materials & Methods: The present study was conducted on 48 patients of OSMF of both genders (males- 32, females- 16). General information such as name, age, gender etc. was recorded. Patients were put on 1500 IU of Hyaluronidase. In all patients, mouth opening was measured before and after treatment. Pain was measured on VAS before and after treatment. Results: Out of 48 patients, male were 36 and females were 12. Mouth opening before treatment was 26.8 mm, at 1 month was 35.2 mm and at 3 months was 40.6 mm. The difference was significant (P< 0.05). Mean burning sensation on VAS score was 7.2 before treatment, 5.4 at 1 month and 2.3 at 3 months. The difference was significant (P< 0.05). Conclusion: Authors found significant improvement in mouth opening and reduction in burning sensation with hyaluronidase.
Key words: Burning, Hyaluronidase, OSMF

Corresponding author: Dr. Archana Kumari, Senior Resident (Dental), Sri Krishna Medical College, Muzaffarpur, Bihar, India

This article may be cited as: Kumari A, Roy S. Efficacy of Hyaluronidase in Management of OSMF- A Clinical Study. J Adv Med Dent Scie Res 2016;4(6):299-301.