Background: OSMF is a potentially malignant disease that results in alteration in Superoxide dismutase (SOD) and glutathione peroxidase levels. The present study was conducted to determine Superoxide dismutase (SOD) and glutathione peroxidase level in patients with OSMF. Materials & Methods: The present study was conducted on 60 subjects with OSMF of both genders. Equal number of controls was also included. In all subjects, Superoxide dismutase level and Glutathione peroxidase assay level was measured
Results: Both group I and II comprised of 60 subjects each. The mean level of Superoxide dismutase (SOD) in group I was 102.3 U/ml and in group II was 204.7 U/ml. The mean glutathione peroxidase (GPx) level in group I was 24.6 U/g Hb in group I and 62.5 U/g Hb in group II. Conclusion: There was reduction in both Superoxide dismutase & glutathione peroxidase as compared to control subjects.
Key words: Glutathione peroxidase, OSMF, Superoxide dismutase.
Received: 15 December 2018 Revised: 27 December 2018 Accepted: 28 December 2018
Corresponding Author: Dr Samir Jain, MDS, Orthodontics, Swastik Dental Clinic, Near SSP Kothi, Gaya College Road, Gaya, (Bihar) 823001
This article may be cited as: Shekhar S, Jain S, Priya P. Assessment of Serum Antioxidant Enzymes Superoxide Dismutase (SOD) and Glutathione Peroxidase in Oral Submucous Fibrosis. J Adv Med Dent Scie Res 2019;7(1):1-4.