Journal of AdvancedMedical and Dental Sciences Research

Background: Hyperglycemia is common in acute illness, even in the absence of known prior insulin resistance or diabetes mellitus (DM). This stress hyperglycemia is due to elevated cortisol, glucagon, growth hormone, catecholamines, and various cytokines, which stimulate glycogenolysis and gluconeogenesis, resulting in a transient increase in blood glucose concentration that typically normalizes when the stress abates. Aim of the study: To evaluate the association between insulin metabolic disorders and pediatric stress hyperglycemia.Materials and methods: The present study was conducted in the Department of Pediatrics of the medical institute. For the study, we selected patients admitted in the ward of Department of Pediatrics. Blood glucose greater than 200 mg/dl was considered as hyperglycemia. Patients diagnosed with diabetes, receiving β agonist drugs or those, chronic renal or hepatic disease, or cystic fibrosis were excluded from the study. At the admission, we recorded patient’s height, weight, BMI, and blood pressure. After 12 hours of fasting fading blood sugar, triglyceride, cholesterol levels and insulin levels were measured. A single dose of 1.75 g/kg of glucose was administered to the subjects and blood glucose was determined after 2 hours. Results: The mean age of the subjects was 10.57 years. The mean weight of the subjects was 32.87 kg, mean height is 1.28 m, mean BMI is 22.77 and mean systolic blood pressure is 107.87 mmHg. Glucose tolerance impairment was seen in 3 patients, BMI> 95th percentile was seen in 10 patients, systolic blood pressure >95th percentile was seen in 5 patients, HDL < 5th percentile was seen in 9 patients, triglycerides >95th percentile was seen in 20 patients, and insulin resistance was seen in 19 patients. Conclusion: We conclude that the risk of progression of stress hyperglycemia to diabetes mellitus is low; however, there is high prevalence of insulin resistance in these patients
Key words: Diabetes mellitus, hyperglycemia, insulin sensitivity, stress hyperglycemia.

Corresponding Author: Dr. Manju Tripathi, Assistant professor, Department of Pediatrics, TS Mishra Medical College and Hospital, Lucknow, Uttar Pradesh, India

This article may be cited as: Tripathi M. Insulin Metabolic Disorders and Pediatric Stress Hyperglycemia. J Adv Med Dent Scie Res 2016;4(3):141-144.