Journal of AdvancedMedical and Dental Sciences Research

Background: Gallstones, or choleliths, are solid masses formed from bile precipitates. The sensitivity of Liver Function Tests [LFTs] in detecting obstructions in bile flow has been found to be greater than 90%. AST (aspartate aminotransferase) and ALT (alanine aminotransferase) are generally considered a measure of hepatocellular function. ALP (alkaline phosphatase) levels are increased during obstruction of the biliary duct system; bilirubin levels can increase due to hemolysis or obstruction of the flow of bile. Hence; we planned the present study to assess the effect of laparoscopic cholecystectomy in the hepatic profile of gallstone patients.Materials & methods: We planned the present study to assess of effect of LC on the hepatic profile of gall stone patients. A total of 40 patients were included in the present study. All the patients underwent LC under general anaesthesia. Assessment of liver functions was done after 24 hours and on 10th day of surgery. Following parameters were studied: ALT (alanine transaminase), AST (aspartate transaminase) and ALP (alkaline phosphatase). All the results were analyzed by SPSS software version 16.0. Results: We observed significant rise in the mean hepatic profile of the patients 24 hours after surgery followed by returning the values to within preoperative range tenth day after surgery.Conclusion:hepatic profile of the gallstone patients is transiently affected by LC procedure.
Key words: Gallstones, Hepatic, Laparoscopic cholecystectomy

Corresponding author: Dr. Ram Shringar Dubey, Assistant Professor, General Surgery/Medical Superintendent, TS Mishra Medical College Lucknow, Uttar Pradesh, India

This article may be cited as: Dubey RS. Evaluation of Effect of Laparoscopic Cholecystectomy on Hepatic Profile of Gallstone Patients: A Clinical Study. J Adv Med Dent Scie Res 2017;5(12):137-139.